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The BIOS group develops ultra-sensitive spectroscopy and sensing technologies for real-time, label-free and high-throughput detection and analysis of very low quantities of biomolecules. We employ a variety of nanophotonic technologies including nanoplasmonics and metamaterials. We integrate our on-chip sensor technologies with micro/nanofluidic systems for efficient analyte trapping and manipulation. We introduce new fabrication schemes that can enable high-throughput fabrication of our technologies at low costs over large areas. In addition to biochemical sensing and spectroscopy, we also investigate nanophotonics to develop devices for on-chip optical communications.